Advanced Glycosylation End Products and Nutrition—A Possible Relation with Diabetic Atherosclerosis and How to Prevent It
نویسندگان
چکیده
منابع مشابه
Advanced glycation end products and diabetic nephropathy.
Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy. Their importance as downstream mediators of tissue in...
متن کاملAdvanced Glycation End Products and Diabetic Complications
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy, neuropathy, cardiomyopathy along with some other di...
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Quality is assessed on the basis of adequate evidence, while best results of the research are accomplished through scientific knowledge. Information contained in a scientific work must always be based on scientific evidence. Guidelines for genuine scientific research should be designed based on real results. Dynamic research and use correct methods of scientific work must originate from eve...
متن کاملImmunohistochemical detection of advanced glycosylation end products in diabetic tissues using monoclonal antibody to pyrraline.
Pyrraline is one of the major Maillard compounds resulting from the reaction of glucose with amino compounds at slightly acidic pH. For in vivo studies, monoclonal pyrraline antibodies were raised after immunization of Balb/c mice with keyhole limpet hemocyamin-caproyl pyrraline conjugate. Of 660 hybridoma clones from one donor, 260 produced an antibody to the free hapten, two of which named Py...
متن کاملAdvanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells.
OBJECTIVE Both advanced glycosylation end products (AGEs) and dendritic cells (DCs) have been shown to play a causative role in atherosclerosis. However, whether they function interactively in the process remains uncertain. We therefore studied the effects of AGE-bovine serum albumin (AGE-BSA) on the maturation of DCs and the expressions of scavenger receptor-A (SR-A) and receptor for AGEs (RAG...
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ژورنال
عنوان ژورنال: Journal of Food Science
سال: 2007
ISSN: 0022-1147,1750-3841
DOI: 10.1111/j.1750-3841.2007.00508.x